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Joao A Paulo Selected Research

Ubiquitin

3/2024Biallelic USP14 variants cause a syndromic neurodevelopmental disorder.
10/2023The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.
1/2023PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems.
1/2019Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
10/2015The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy.

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Joao A Paulo Research Topics

Disease

25Neoplasms (Cancer)
06/2024 - 09/2014
13Chronic Pancreatitis
09/2014 - 08/2010
8Pancreatic Diseases (Pancreatic Disease)
10/2015 - 12/2011
7Infections
12/2023 - 10/2016
7Pancreatic Neoplasms (Pancreatic Cancer)
11/2023 - 03/2012
5Neurodegenerative Diseases (Neurodegenerative Disease)
06/2024 - 01/2021
5Glaucoma
06/2024 - 01/2021
5Inflammation (Inflammations)
08/2023 - 03/2012
5Adenocarcinoma
01/2021 - 09/2014
5Abdominal Pain (Pain, Abdominal)
03/2013 - 08/2010
4Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
06/2024 - 07/2015
4Leukemia
12/2023 - 01/2019
4Type 2 Diabetes Mellitus (MODY)
01/2023 - 01/2013
3Alzheimer Disease (Alzheimer's Disease)
06/2024 - 01/2021
3Parkinson Disease (Parkinson's Disease)
06/2024 - 10/2015
3COVID-19
12/2023 - 09/2023
3Obesity
01/2023 - 01/2020
3Metabolic Diseases (Metabolic Disease)
11/2022 - 01/2019
3Starvation
10/2022 - 10/2011
3Fibrosis (Cirrhosis)
09/2014 - 06/2011
2Macular Degeneration (Age-Related Maculopathy)
06/2024 - 08/2023
2Mitochondrial Diseases (Mitochondrial Disease)
03/2024 - 03/2022
2Neurodevelopmental Disorders
03/2024 - 01/2024
2Respiratory Tract Infections (Respiratory Tract Infection)
11/2023 - 09/2023
2Neuroblastoma
11/2023 - 01/2018
2Nervous System Diseases (Neurological Disorders)
10/2023 - 01/2018
2Breast Neoplasms (Breast Cancer)
01/2023 - 12/2013
2Hypoxia (Hypoxemia)
01/2023 - 01/2021
2Cardiomyopathies (Cardiomyopathy)
11/2022 - 01/2021
2Neuroinflammatory Diseases
10/2022 - 10/2022
2Multiple Sclerosis
10/2022 - 01/2021
2Multiple Myeloma
03/2022 - 01/2021
2Melanoma (Melanoma, Malignant)
01/2020 - 12/2016
2Genomic Instability
01/2018 - 01/2017
2Cysts
09/2017 - 08/2012
2Pancreatitis
10/2013 - 03/2013
2Exocrine Pancreatic Insufficiency
01/2013 - 03/2012
2Pancreatic Cyst
08/2012 - 01/2012
1Traumatic Brain Injuries (Traumatic Brain Injury)
06/2024
1Cardiovascular Diseases (Cardiovascular Disease)
06/2024
1Colorectal Neoplasms (Colorectal Cancer)
04/2024
1Brain Injuries (Brain Injury)
03/2024
1Stroke (Strokes)
03/2024
1Familial encephalopathy with neuroserpin inclusion bodies
03/2024
1Proteostasis Deficiencies
01/2024
1Vaccinia
12/2023
1Coronavirus Infections
11/2023
1Autistic Disorder (Autism)
10/2023

Drug/Important Bio-Agent (IBA)

51Proteins (Proteins, Gene)FDA Link
06/2024 - 06/2011
9ProteomeIBA
12/2023 - 08/2011
9Biomarkers (Surrogate Marker)IBA
10/2013 - 04/2011
6DNA (Deoxyribonucleic Acid)IBA
11/2023 - 01/2017
5UbiquitinIBA
03/2024 - 10/2015
4Retinaldehyde (Retinal)IBA
06/2024 - 10/2022
4ChromatinIBA
11/2023 - 01/2020
4Glucose (Dextrose)FDA LinkGeneric
08/2023 - 01/2013
4EnzymesIBA
01/2018 - 01/2012
4NicotineFDA Link
01/2018 - 05/2013
3IronIBA
04/2024 - 01/2021
3CytokinesIBA
08/2012 - 06/2011
2Amyloid beta-PeptidesIBA
06/2024 - 08/2023
2Phosphatidylinositols (Phosphatidylinositol)IBA
12/2023 - 01/2020
2Antiviral Agents (Antivirals)IBA
12/2023 - 01/2020
2Viral ProteinsIBA
12/2023 - 01/2019
2Calcium-Binding ProteinsIBA
01/2023 - 09/2017
2Amyloid (Amyloid Fibrils)IBA
01/2023 - 10/2022
2Ligases (Synthetase)IBA
01/2023 - 01/2019
2Messenger RNA (mRNA)IBA
01/2023 - 10/2017
2Protein Isoforms (Isoforms)IBA
12/2022 - 01/2012
2LipidsIBA
12/2022 - 01/2022
2Fatty Acids (Saturated Fatty Acids)IBA
10/2022 - 01/2019
2Phosphotransferases (Kinase)IBA
10/2022 - 01/2020
2TropomyosinIBA
10/2022 - 09/2017
2Immune Checkpoint InhibitorsIBA
03/2022 - 01/2022
2EpitopesIBA
01/2022 - 09/2017
2FilaminsIBA
01/2021 - 03/2012
2Histones (Histone)IBA
01/2020 - 01/2018
2Serotonin (5 Hydroxytryptamine)IBA
01/2017 - 01/2012
2Complement System Proteins (Complement)IBA
01/2017 - 12/2013
2SecretinFDA Link
03/2013 - 08/2011
2Inosine Monophosphate (IMP)IBA
08/2012 - 01/2012
1tau Proteins (tau Protein)IBA
06/2024
1Reactive Oxygen Species (Oxygen Radicals)IBA
04/2024
1Transferrin (beta 2 Transferrin)IBA
03/2024
1FibrinolysinFDA Link
03/2024
1Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
03/2024
1Tissue Plasminogen Activator (Alteplase)FDA Link
03/2024
1NeuroserpinIBA
03/2024
1Proteasome Endopeptidase Complex (Proteasome)IBA
03/2024
1ATPases Associated with Diverse Cellular ActivitiesIBA
01/2024
1Purinergic Receptors (Receptors, Purine)IBA
12/2023
1GTP-Binding Proteins (G-Protein)IBA
12/2023
1Cytarabine (Cytosar-U)FDA LinkGeneric
12/2023
1VaccinesIBA
12/2023
13- (2- methoxyphenyl)- 5- methoxy- 1,3,4- oxadiazol- 2(3H)- oneIBA
12/2023
1InflammasomesIBA
12/2023
1Angiotensin-Converting Enzyme 2IBA
12/2023
1Dronabinol (THC)FDA LinkGeneric
11/2023

Therapy/Procedure

10Therapeutics
12/2022 - 10/2013
2Immunotherapy
01/2022 - 01/2019